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Search Results for " nav1.7 inhibitor 1 "

10

Compounds

Cat No. Product Name Synonyms Targets
T12181 NaV1.7 inhibitor-1 Sodium Channel
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
T50030 1-(2,4-difluorophenyl)guanidine hydrochloride Others
1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signali...
T79398 Ancistrotecine B Sodium Channel
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].
T80450 Pe1b μ-TrTx-Pe1b Sodium Channel
Pe1b (μ-TrTx-Pe1b) is a selective inhibitor of the NaV1.7 channel, exhibiting an inhibitory concentration 50 (IC50) value of 167 nanomolar (nM) [1].
T80435 Heteropodatoxin-1 Potassium Channel
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9 channels. However, it has no effect on Nav1.8 channels [1].
T80439 GTx1-15 Sodium Channel
GTx1-15, an inhibitor cystine knot (ICK) peptide, antagonizes the voltage-dependent calcium channel Cav3.1, as well as voltage-dependent sodium channels Nav1.3 and Nav1.7 [1].
T80445 Phlo1a μ-TrTx-Phlo1a Sodium Channel
Phlo1a (μ-TrTx-Phlo1a), a 35-amino acid peptide toxin, demonstrates a weak inhibitory effect on Nav1.2 and Nav1.5 channels [1]. Meanwhile, Phlo1b acts as a selective inhibitor of the Nav1.7 channel.
T80519 M3-Huwentoxin IV m3-HwTx-IV Sodium Channel
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6.8 nM for hNaV1.6, 7.2 nM for hNaV1.3, 8.4 nM for hNaV1.1, 1...
T80494 Tap1a TRTX-Tap1a,Theraphotoxin-Tap1a,µ/ω-TRTX-Tap1a Sodium Channel
Theraphotoxin-Tap1a (Tap1a) is a spider venom-derived peptide that acts as an inhibitor of sodium channels, displaying IC50 values of 80 nM for Na v 1.7 and 301 nM for Na v 1.1. It demonstrates analgesic effects [1].
T80169 ProTx-III μ-TRTX-Tp1a Sodium Channel
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium channel Na v 1.7, exhibiting an IC 50 of 2.1 nM. Characterized...
TargetMol